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MM, Bloomer RJ. Impact of caloric and dietary restriction regimens on markers of health and longevity in humans and animals: a summary of available findings. Nutr J. 2011;10:107. https://pubmed.ncbi.nlm.nih.gov/21981968/

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Schmidt JA, Rinaldi S, Scalbert A, et al. Plasma concentrations and intakes of amino acids in male meat-eaters, fish-eaters, vegetarians and vegans: a cross-sectional analysis in the EPIC-Oxford cohort. Eur J Clin Nutr. 2016;70(3):306–12. https://pubmed.ncbi.nlm.nih.gov/26395436/

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Green CL, Lamming DW, Fontana L. Molecular mechanisms of dietary restriction promoting health and longevity. Nat Rev Mol Cell Biol. 2022;23(1):56–73. https://pubmed.ncbi.nlm.nih.gov/34518687/

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Yu D, Yang SE, Miller BR, et al. Short-term methionine deprivation improves metabolic health via sexually dimorphic, mTORC1-independent mechanisms. FASEB J. 2018;32(6):3471–82. https://pubmed.ncbi.nlm.nih.gov/29401631/

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Elshorbagy AK, Valdivia-Garcia M, Mattocks DAL, et al. Cysteine supplementation reverses methionine restriction effects on rat adiposity: significance of stearoyl-coenzyme A desaturase. J Lipid Res. 2011;52(1):104–12. https://pubmed.ncbi.nlm.nih.gov/20871132/

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Le LT, Sabaté J. Beyond meatless, the health effects of vegan diets: findings from the Adventist cohorts. Nutrients. 2014;6(6):2131–47. https://pubmed.ncbi.nlm.nih.gov/24871675/

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Tonstad S, Stewart K, Oda K, Batech M, Herring RP, Fraser GE. Vegetarian diets and incidence of diabetes in the Adventist Health Study-2. Nutr Metab Cardiovasc Dis. 2013;23(4):292–9. https://pubmed.ncbi.nlm.nih.gov/21983060/

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Dong Z, Gao X, Chinchilli VM, et al. Association of dietary sulfur amino acid intake with mortality from diabetes and other causes. Eur J Nutr. 2022;61(1):289–98. https://pubmed.ncbi.nlm.nih.gov/34327571/

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Dong Z, Gao X, Chinchilli VM, et al. Association of dietary sulfur amino acid intake with mortality from diabetes and other causes. Eur J Nutr. 2022;61(1):289–98. https://pubmed.ncbi.nlm.nih.gov/34327571/

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Dong Z, Gao X, Chinchilli VM, et al. Association of sulfur amino acid consumption with cardiometabolic risk factors: cross-sectional findings from NHANES III. EClinicalMedicine. 2020;19:100248. https://pubmed.ncbi.nlm.nih.gov/32140669/

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López-Torres M, Barja G. Lowered methionine ingestion as responsible for the decrease in rodent mitochondrial oxidative stress in protein and dietary restriction possible implications for humans. Biochim Biophys Acta. 2008;1780(11):1337–47. https://pubmed.ncbi.nlm.nih.gov/18252204/

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Di Buono M, Wykes LJ, Ball RO, Pencharz PB. Dietary cysteine reduces the methionine requirement in men. Am J Clin Nutr. 2001;74(6):761–6. https://pubmed.ncbi.nlm.nih.gov/11722957/

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Elshorbagy AK, Valdivia-Garcia M, Mattocks DAL, et al. Cysteine supplementation reverses methionine restriction effects on rat adiposity: significance of stearoyl-coenzyme A desaturase. J Lipid Res. 2011;52(1):104–12. https://pubmed.ncbi.nlm.nih.gov/20871132/

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Duran-Ortiz S, List EO, Basu R, Kopchick JJ. Extending lifespan by modulating the growth hormone/insulin-like growth factor-1 axis: coming of age. Pituitary. 2021;24(3):438–56. https://pubmed.ncbi.nlm.nih.gov/33459974/

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Schmidt JA, Rinaldi S, Scalbert A, et al. Plasma concentrations and intakes of amino acids in male meat-eaters, fish-eaters, vegetarians and vegans: a cross-sectional analysis in the EPIC-Oxford cohort. Eur J Clin Nutr. 2016;70(3):306–12. https://pubmed.ncbi.nlm.nih.gov/26395436/

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Lederer AK, Maul-Pavicic A, Hannibal L, et al. Vegan diet reduces neutrophils, monocytes and platelets related to branched-chain amino acids – a randomized, controlled trial. Clin Nutr. 2020;39(11):3241–50. https://pubmed.ncbi.nlm.nih.gov/32147197/

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Tanrikulu-Kucuk S, Ademoglu E. Dietary restriction of amino acids other than methionine prevents oxidative damage during aging: involvement of telomerase activity and telomere length. Life Sci. 2012;90(23–24):924–8. https://pubmed.ncbi.nlm.nih.gov/22564407/

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Solon-Biet SM, Mitchell SJ, de Cabo R, Raubenheimer D, Le Couteur DG, Simpson SJ. Macronutrients and caloric intake in health and longevity. J Endocrinol. 2015;226(1):R17–28. https://pubmed.ncbi.nlm.nih.gov/26021555/

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Solon-Biet SM, Cogger VC, Pulpitel T, et al. Branched chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control. Nat Metab. 2019;1(5):532–45. https://pubmed.ncbi.nlm.nih.gov/31656947/

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Lu J, Temp U, Müller-Hartmann A, Esser J, Grönke S, Partridge L. Sestrin is a key regulator of stem cell function and lifespan in response to dietary amino acids. Nat Aging. 2021;1(1):60–72. https://pubmed.ncbi.nlm.nih.gov/37117991/

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Richardson NE, Konon EN, Schuster HS, et al. Lifelong restriction of dietary branched-chain amino acids has sex-specific benefits for frailty and lifespan in mice. Nat Aging. 2021;1(1):73–86. https://pubmed.ncbi.nlm.nih.gov/33796866/

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Richardson NE, Konon EN, Schuster HS, et al. Lifelong restriction of dietary branched-chain amino acids has sex-specific benefits for frailty and lifespan in mice. Nat Aging. 2021;1(1):73–86. https://pubmed.ncbi.nlm.nih.gov/33796866/

8038

Green CL, Lamming DW, Fontana L. Molecular mechanisms of dietary restriction promoting health and longevity. Nat Rev Mol Cell Biol. 2022;23(1):56–73. https://pubmed.ncbi.nlm.nih.gov/34518687/

8039

Solon-Biet SM, Mitchell SJ, de Cabo R, Raubenheimer D, Le Couteur DG, Simpson SJ. Macronutrients and caloric intake in health and longevity. J Endocrinol. 2015;226(1):R17–28. https://pubmed.ncbi.nlm.nih.gov/26021555/

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Lee MB, Hill CM, Bitto A, Kaeberlein M. Antiaging diets: Separating fact from fiction. Science. 2021;374(6570):eabe7365. https://pubmed.ncbi.nlm.nih.gov/34793210/

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Cordain L, Lindeberg S, Hurtado M, Hill K, Eaton SB, Brand-Miller J. Acne vulgaris: a disease of Western civilization. Arch Dermatol. 2002;138(12):1584–90. https://pubmed.ncbi.nlm.nih.gov/12472346/

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Melnik BC, John SM, Plewig G. Acne: risk indicator for increased body mass index and insulin resistance. Acta Derm Venereol. 2013;93(6):644–9. https://pubmed.ncbi.nlm.nih.gov/23975508/

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Blair MC, Neinast MD, Arany Z. Whole-body metabolic fate of branched-chain amino acids. Biochem J. 2021;478(4):765–76. https://pubmed.ncbi.nlm.nih.gov/33626142/

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Neinast M, Murashige D, Arany Z. Branched chain amino acids. Annu Rev Physiol. 2019;81:139–64. https://pubmed.ncbi.nlm.nih.gov/30485760/

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Tournissac M, Vandal M, Tremblay C, et al. Dietary intake of branched-chain amino acids in a mouse model of Alzheimer’s disease: effects on survival, behavior, and neuropathology. Alzheimers Dement (N Y). 2018;4:677–87. https://pubmed.ncbi.nlm.nih.gov/30560200/

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Larsson SC, Markus HS. Branched-chain amino acids and Alzheimer’s disease: a Mendelian randomization analysis. Sci

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